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G1E-ER4 is a subclone of GATA-1 null erythroblasts which stably expresses a GATA-1-ER (estradiol receptor ligand binding domain) fusion protein 32

Called tyrosine kinase inhibitors (TKIs), these agents bind to HER2 receptors on the cancer cell surface, thereby blocking the receptor signals that tell breast cancer cells to keep growing: Lapatinib (Tykerb ) received FDA approval in 2007 for HER2-positive breast cancer treatment in patients already treated with capecitabine (chemotherapy)